Abstract:Objective：Analysis of the epidemic status and related factors of stroke among middle-aged and elderly people in China. Methods：In this study，Chi-square test and Logistic regression analysis were used to analyze the CHARLS survey data. Results：Of the 18，763 participants in the study，951 had stroke. The prevalence of stroke was 5.07%，5.55% in males and 5.15% in females，respectively. According to the epidemiological distribution characteristics，there were significant differences in the prevalence of stroke among middle-aged and elderly people in different age，region，household registration，marital status，education level and hypertension，dyslipidemia，diabetes，heart disease and depression（P < 0.05），while there was no significant difference in the prevalence of stroke among different ethnic groups（P > 0.05）. Logistic regression showed that the main risk factors associated with stroke were age，region，hypertension，diabetes，dyslipidemia，heart disease and depression. Conclusions：The prevention and treatment of stroke in middle-aged and elderly people in China should carry out targeted intervention measures according to the epidemic status and risk factors.