Abstract:Objective：UsingFailure Mode and Effects Analysis (FMEA)method，to develop interventions studio，and to reduce the risk of nosocomial infection in ICU and ensure medical safety. Methods：Using FMEA technology，a risk assessment team was established to analyze the failure modes and reasons leading to the high incidence of nosocomial infection in the department of serious illness medicine，to find out the failure modes that need to be improved，to develop effective intervention measures，and to carry out a three-month intervention study. The nosocomial infection of patients in the intervention group and the control group were compared to evaluate the intervention effect. Results：The nosocomial infection rate，and the nosocomial infection rate，the incidence of ventilators associated pneumonia，the incidence of central venous catheter-associated bloodstream infections in the intervention groupwas lower than that in the control group. The hand hygiene compliance rate and accuracy rate of medical staff in the intervention group were improved.The qualified rate of the comprehensive monitoring of cleaning and disinfection of ICU staff's sanitary hands，surface of objects，ground and instruments showed a rising trend. Conclusion：Reasonable use of FMEA analysis can reduce the risk of nosocomial infection in ICU，improve the rate and accuracy of hand hygiene of ICU hospital staff，and play a positive role in improving the cleaning and disinfection effect of medical staff on hand hygiene，object surface，ground and instruments.