Abstract:Objective：To study the economic burden of infection after gastric carcinoma surgery，and to analyze the cost- benefit of infection prevention and control after gastric carcinoma surgery. Methods：All patients who underwent gastric carcinoma surgery in gastric surgery department from January 1，2022 to December 31，2022 were retrospectively investigated，and various medical expenses and hospitalization days were compared between the two groups. According to the infection rate，operation volume，hospitalization cost per patient，the number of patients less admitted due to infection and the reduced income，the benefits of the nosocomial infection prevention and control project in gastric surgery department were calculated，and make suggestions on refined payment of medical insurance expenses. Results：The length of hospital stay in the infection group was 34 days，which was higher than that in the non-infection group 14 days，and the difference between the two groups was statistically significant（P < 0.05）. The total cost of hospitalization in the infection group was 127 176.99 yuan，which was higher than 66 161.03 yuan in the non-infection group（P < 0.05）. If the implementation of prevention and control measures for nosocomial infection in gastric cancer surgery，when the incidence of infection is reduced by 10%，the beneficence-cost ratio can reach 1.15. At the same time，it has important exploratory significance for refined value-based medical payment. Conclusion：The implementation of nosocomial infection prevention and control project can not only reduce the financial burden of patients，increase the income of the hospital.The quality of hospital infection management directly has an important impact on medical insurance payment；adjusting DRG payment based on the incidence of preventable infections has certain exploratory value in improving the current medical insurance payment policy.