Abstract:Objective：This study aimed to explore feasible measures to prevent and control COVID-19 and boost development of industries via a questionnaire to investigate personnel’s preference for the changed prevention and control measures of COVID-19 in China after it’s managed with measures against Class-B infectious diseases and identify the influencing factors of psychological stress. Methodology：1012 people in total were surveyed in various industries of 18 provinces（including the retired）from Feb 3rd，2023 to Feb 27th，2023 via Wenjuanxing（an online questionnaire design platform）and WeChat（questionnaire release app）to learn about their preference for the changed prevention and control measures against COVID-19 before and after it’s managed with measures against Class-B infectious diseases. Relevant data were aggregated and analyzed to discuss reasons and explore a COVID-19 prevention and control mode more beneficial to the survival，life and development of personnel in various industries. Results：Before government announces to manage COVID-19 with measures against Class-B infectious diseases，COVID-19 prevention and control policies had different impacts on personnel at different ages and from different occupations，which had a comparatively bigger impact on healthcare providers and those in service industry like catering services，but a comparatively smaller impact on teachers，students and the retired. Based on the logistic regression model of various factors，centralized isolation/home isolation，building/community lockdown，and mandatory COVID-19 testing for exit and entry in different cities or specific public places are the factors causing psychological stress（P＜0.05）. Conclusion：people more prefer the prevention and control measures after COVID-19 is managed with measures against Class-B infectious diseases.