Abstract:Objective：To study the living conditionsand psychological changes of retired comrades inmedical institutions with medical professional and technical background during the COVID-19 pandemic，and to analyze the influencing factors. To provide data support for the subsequent psychological intervention. Methods：A study design of cross-sectional survey was used.A total of 220 retired comrades in medical institutions from Suzhou were randomly enrolled to complete the anonymous questionnaire. Percentage with ratio was used to describe the data distribution，and chi-square testwas used to analyze the differences between different groups. Results：Total of 220 questionnaires were distributed and 212 questionnaires were collected，with a recovery rate of 96.36%. 87.26%（185/212）of the subjects reported that the outbreak had affected the normal pace of life. 76. 43% （162/212）of subjects claimedthat the outbreak affected normal sleep；18.87% （40/212）of the subjects reported dietary problems such as loss of appetite；82. 55 % （175/212）reportedthat the outbreak had changed their original social interaction. 58.96% （125/212）of the subjects reported that the COVID-19 pandemic had led to negative changes in psychological conditions；The main negative psychologicalchanges are shown as follows：25.00%（53/212） of the subjects claimedthat they had anxiety，depression and other psychological changes；12.26%（26/212） of the subjects reported compulsive symptoms of repeated hand washing and repeated home environment disinfection；7.55% （16/212）subjects reported somatic symptoms of phytologic disorders. The negative changes in life status and psychological occurrence are significantly associated with age（P＜0.05）. Conclusions：COVID-19 had a negative impact on the living and psychological conditions of retired comrades in medical institutions. Their children，relatives，and staff from the office of retirement services should take the initiative to care about the psychological problems of retired comrades in medical institutions.