Abstract:Objective：To explore a scientific research management model to improve the scientific and technological innovation capabilities of district and county-level hospitals under the background of high-quality development of public hospitals. Methods：We investigated the internal and external environmental situation of Nanjing Jiangning Hospital’s scientific and technological innovation work through brainstorming and SWOT method，analyzed and discussed the key links，and proposed innovative measures for scientific research management，mainly including improving the management system construction，emphasizing the introduction and training of talents，improving the assessment mechanism，comprehensively strengthen the cooperation between hospitals and universities，promote the construction of scientific research integrity，etc. Finally，we analyzed the improvement effect of the above measures on the hospital’s scientific and technological innovation work after the implementation. Results：After the implementation of scientific research management innovation measures，the project application enthusiasm of hospital researchers，as well as the quantity and quality of sponsored project were significantly improved. The scientific research funds have also increased. In addition，the number of high-quality research papers has also increased significantly. Conclusion：The development of scientific and technological work in district and county-level hospitals is facing a series of problems that need to be solved urgently. Building a scientific research management system that is in line with the actual situation of the hospital can effectively promote the improvement of the level of scientific and technological innovation in the hospital，and then promote the high-quality development of the hospital.