Abstract:Objective：To describe the etiology and clinical characteristics of patients with cirrhosis in a certaincity，and to analyze the clinical characteristics and hospitalization costs of patients with cirrhosis of different etiology，so as to provide reference for the clinical diagnosis and treatment of cirrhosis and the medical decision-making of related departments. Methods：Information of discharged patients with main diagnosis ICD-10 code K70.2，K70.3，K71.7，K74，K76.1 and P78.8 from a certaintertiary infectious disease specialized hospital in 2021 was collected，including：gender，age，clinical features，total hospitalization expenses and details. Chi-square test and nonparametric test were used to analyze the clinical features and hospital expenses of patients with cirrhosis of different etiology. Results：The main cause of liver cirrhosis was viral infection，accounting for 64.6%，and the main clinical feature was varicose veins，accounting for 26.5%. The rates of infectious diseases and varicose veins were different in cirrhosis patients of different ages. The incidence of infectious diseases，portal hypertension，varicose veins and electrolyte disorders were different in patients with cirrhosis with different etiologies，and the differences were statistically significant. There were significant differences in the total cost of hospitalization among patients with cirrhosis of different ages and causes. Conclusion：The etiology of patients with cirrhosis should be clearly identified and active treatment should be conducted according to the etiology and clinical characteristics to prevent or delay the further deterioration of the disease. Standardize diagnosis and treatment，rational drug use and prevent excessive examination to effectively control hospital expenses.