Abstract:Objective：To explore the application effect of problem oriented teaching mode in clinical teaching of ultrasound. Method：A total of the 82 interns who underwent clinical internships in the Ultrasound Department of our hospital from March 2021 to June 2022 and achieved comparable results in their professional course proficiency tests were selected as the research subjects. They were randomly divided into a reference group and a research group，with 41 students in each group. The reference group implemented a teaching model of guidance and guidance，while the research group adopted a problem oriented teaching model on the basis of traditional teaching. Compare the assessment results（theoretical scores，practical scores，and film reading scores）and teaching effectiveness of two groups of interns after completing their internship. Results：It’s showed that the theoretical，practical，and film reading scores of the research group interns were higher than those of the reference group，and the teaching effectiveness score was higher than that of the reference group（P < 0.05）. Conclusion：The active application of problem oriented teaching mode in clinical teaching of ultrasound can achieve more ideal teaching effects，effectively improve interns’ theoretical and practical performance，as well as thinking abilities，and help them better improve relevant operational skills.