Abstract:Objective：To explore the innovation of disease cost management mode under DIP payment，and provide decision-making reference for further strengthening disease cost control and promoting hospital refined management. Methods：A certain grade A tertiary public hospital in Huai’an City，was selected as the practical research object，and the service unit superposition method was used for disease cost accounting. Results：The precise calculation of disease cost promotes hospital cost reduction and efficiency increase；Reasonable medication management can effectively control the unreasonable increase in drug costs. The combination of clinical pathway and DIP disease score management has achieved effective control of disease cost（P < 0.05）. Reducing postoperative complications is beneficial for reducing medical resource consumption. Conclusion：The DIP payment model promotes the transformation of hospital cost management，achieving effective control of disease costs through various methods such as disease profit and loss，rational drug use，and clinical pathway management，greatly improving the efficiency of medical insurance fund utilization.