Abstract:Objective：To investigate and analyze the mental health status and influencing factors of medical staff during COVID-19 epidemic. Methods：It chooses a professional platform what is named “Wenjuanxing” for data collection questionnaire survey，including general information，generalized anxiety disorder-7（GAD-7），patient health questionnaire（PHQ-9）and Stanford Acute Stress Response Questionnaire（SASRQ）. Results：2，263 questionnaires were collected，and 412medical staff（18.20%）had anxiety，457（20.19%）had depression，and 371（16.39%）had ASD（acute stress disorders）. The scores of anxiety and depression，SASRQ，separation symptoms，reexperience symptoms，avoidance symptoms，irritation symptoms and functional impairment symptoms of anti epidemic medical staff were significantly higher than those of normal working staff and those who were under control at home（P < 0.001）. Among the ASD medical staff，258（69.54%）had anxiety，276（74.39%）had moderate depression，and 203（54.72%）had severe depressive symptoms. Regression analysis showed that male，anxiety and depression were the influencing and predictive factors of ASD in medical staff. Conclusion：The proportion of medical staff with depression，anxiety and stress-related disorders is high during the COVID-19 outbreak. It is particularly important to care for medical staff.