目的：分析疾病诊断相关分组（diagnosis-related groups，DRGs）付费改革前后艾滋病患者住院费用的变化，提出相应成本管控建议。方法：运用双重差分法（Differences-in-Differences，DID）对某三甲传染病医院4394份艾滋病病例的住院费用及住院天数进行平均效应分析。结果：DRG付费实施后，艾滋病患者的住院总费用和耗材费下降明显（P < 0.05），药品费、检查费等无明显变化（P > 0.05），平均住院天数减少2.53天（P < 0.05）。结论：应进一步强化艾滋病药品及检查的控费力度，建议通过搭建信息监控平台、实行院内评审、规范检查流程、应用创新技术等举措，完善艾滋病住院费用的精细化管理。

Objective：The changes of hospitalization expenses of AIDS patients before and after the payment reform of disease diagnosis-related groups（DRGs）were analyzed，and the corresponding cost control suggestions were put forward. Methods：Taking 4，394 AIDS cases in a certain tertiarygrade A infectious disease hospital as the research object，the double difference method（Differences-in-Differences，DID）was used to analyze the average effect of hospitalization cost and hospitalization days. Results：After the implementation of DRG payment，the total hospitalization cost and consumable cost of AIDS patients decreased significantly（P < 0.05），the drug cost and examination fee had no significant change（P > 0.05），and the average hospitalization days decreased by 2.53 days（P < 0.05）. Conclusion：The cost control of AIDS drugs and inspection should be further strengthened.It is suggested to strengthen the fine management of AIDS hospitalization expenses by building an information monitoring platform，conducting in-hospital reviews，standardizing the inspection process，and applying innovative technologies.