Abstract:Objective：To study the changes of the operation efficiency of surgery departments before and after the DRG（diagnosis related groups）payment in a certaintertiary general hospital，and to provide ideas for the fine management of hospital clinical departments under the background of DRG payment. Methods：The operational data of surgical departments in a certain tertiarygeneral hospital from 2019 to 2021 were collected. TheBCC and Malmquist models of data envelopment analysis（DEA）were used for analysis，and the influencing factors were analyzed by Tobit regression. Results：The total factor productivity of surgical departments after DRG payment reform was 1.144，and the technical change index was 1.149. CMI value and number of hospital bed turnover are positively correlated with operation efficiency，while actual open beds，fixed assets and number of DRG groups are negatively correlated with operation efficiency，CMI value is highly correlated. Conclusion：DRG payment can promote the operation efficiency of clinical departments through fine management and technological progress. According to development needs，hospitals can categorically explore the most appropriate DRG-related indicators to be included in the efficiency evaluation system，so as to guide high-quality development.