Abstract:Objective：To explore the effect of DRGs payment reform practice in Changzhou and accumulate pilot experience for expanding the scope of reform. Methods：The data of 16 pilot hospitals in the year beforethe reform and first three quarters after the reform were collected and analyzed，and research the effectiveness of DRGs reformin Changzhou from the aspects of cost management，hospitalization efficiency，hospitalization burden of dominant disease groups，etc. Results：It was found that DRGs payment reform had a positive impact on medical institutions and reducing the burden on patients，and hospitals and patients all got the reform dividend. Conclusion：Changzhou CHS-DRGs reform has explored a medical insurance fund management and control system suitable for the local area，and the reform already makes the preliminary effects. Its pilot experience is worth using for referencein domesticDRGs pilot cities.