Abstract:Objective：To centralize the medical quality management function into one department through the reform of large department system，to avoid the problems of buck-passing，information barriers and inadequate monitoring when the quality control function is dispersed in various departments，so as to build an integrated，whole-process and all-round medical quality closed-loop management system. Methods：Adjust the organizational structure of functional departments，set up a “quality control center” based on the concept of large department system，including medical quality control department，nursing quality control department，medical insurance and price department，medical record room and data center，so as to explore the “large quality control” operation mode. Results：The quality and safety of the whole process of medical treatment were effectively improved，various quality indicators were stable and improved，and the scores of the “National Examination” were steadily improved. Conclusion：The concept of large quality control really separates the quality control function from the management function，realizes standardized management，scientific goal and fine management of medical quality and safety，and promotes the transformation of the hospital to a quality-benefit-oriented high-quality development.