Abstract:Objective：In the case of asymmetric information between doctors and patients，we should look for objective common factors that affect patient safety factors，and explore innovative ways to prevent and control medical risks and ensure patient safety management. Methods：A retrospective summary of 367 disputes occurred in acertain grade Atertiary hospital from 2016 to 2020，and 118 cases of compensation disputes were screened out. Using EXCEL software，the basic situation of disputes was statistically analyzed. Results：Although the number of in-hospital disputes in a certain grade A tertiary hospital from 2016 to 2020 has been decreasing year by year，the number of disputes arising from compensation does increase year by year，and disputes caused by iatrogenic factors also increase year by year. Conclusions：In order to avoid and prevent the medical risk of patient injury caused by iatrogenic factors to the greatest extent，it is necessary to start from the medical staff of the hospital，focus on ex-ante management，and supplement the ex-post management，build a patient safety pre-management structure，and systematically protect the hospital and patients’safety.