Abstract:Objective：To explore the effect of improving nursing intervention on psychological stress and insomnia in young and middle-aged patients with cerebral infarction. Methods：81 young and middle-aged patients with cerebral infarction from October 2020 to May 2022 were selected as the research objects，and were randomly divided into 41 cases in the control group and 40 cases in the observation group. The control group received routine psychological intervention. On this basis，the observation group adopted the concept of acceptance and commitment nursing，1 h/time，once a week，for 6 consecutive weeks. The two groups of patients were evaluated with Zung self-rating Anxiety Scale（SAS），Zung self-rating Depression Scale（SDS）and Pittsburgh sleep quality index（PQSI）before the intervention and at the end of the intervention 6 weeks. Results：At the end of the intervention 6 weeks，the SAS，SDS and PQSI scores of the observation group（47.78 ± 2.45），（54.16 ± 3.61），（7.03 ± 2.69）were significantly lower than those of the control group（52.53 ± 3.28），（56.10 ± 3.95），（8.81 ± 2.38）；The difference was statistically significant（P＜0.05）. Conclusion：By improving nursing intervention，that is，using the concept of acceptance and commitment，nursing can effectively reduce the anxiety and depression of young and middle-aged patients with cerebral infarction and improve their insomnia，which is worthy of clinical application.