Abstract:Objective：To investigate the current status of nurses’perceived professional benefits and occupational stress in a certian Grade-A Tertiary Hospital in Wuxi，and to analyze the factors influencing perceived professional benefit. Methods：A total of 1 193 nurses in the hospital were investigated with general information questionnaire，Nurses’Perceived Professional Benefits Scale and Chinese Nurses Stress Scale. Results：The total score of the nurses’perceived Professional Benefit Scale was（118.35±16.51）and the total score of the Chinese Nurses Stress Scale was（73.47±12.96）. The results of multiple linear regression analysis indicated that average monthly salary（including salary and bonus），average sleep time per day，whether to participate in scientific research work，whether to consider resignation，and work stress were the main influencing factors of nurses’sense of perceived professional benefit（P < 0.05）. Conclusion：Nurses’ sense of perceived professional benefit is in the upper middle level，and their work stress is in the middle level. Average monthly salary，average sleep time per day，whether to participate in scientific research work are the positive influencing factors of nurses’perceived professional benefit，and whether to consider resignation and work stress are the negative influencing factors of nurses’perceived professional benefit. Nursing managers can improve nurses’perceived professional benefits by formulating corresponding intervention measures.