Abstract:Based on the Government procurement law of People Republic of China，Internal control guideline for administrative institutions（Trial）and Fujian provincial government centralized purchasing catalog and quota standard，following the four basic principles of internal control including comprehensiveness，importance，balance，adaptability，the characterization and difficulty of procurement of reagent in the institutions of disease control and prevention were analyzed. Combined with the practice on the procurement of reagent in the recent years，the corresponding measures were put forward to normalize the procurement of the reagent from the aspects of perfecting the internal control system，improving the relevant management institution，strengthening the budget management，grading approval and procurement organization，which in turn to reinforce the internal control on the procurement of reagent and provide better service for the disease control.