Abstract:Objective：To investigate the doctor-patient communication status quo between medical staff and patients in a first-class general hospital. It’s expected to enhance the doctor-patient communication effect and ability for medical staff，and improve the communication satisfaction of the patients as well as provide referent suggestions for the construction of harmonious relationship. Methods：By means of random sampling method，100 medical workers and 100 patients were randomly selected from the hospital to conduct a questionnaire survey. The experience，information，skills，attitudes，influencing factors and other aspects of communication between doctors and patients were studied to compare the different understanding between doctors and patients on doctor-patient communication. Results：There were significant differences in the overall cognition of doctor-patient communication between doctors and patients. The importance of doctor-patient communication was more recognized by doctors（χ2=21.012，P=0.000）；the contents of doctor-patient communication between doctors and patients were inconsistent; the work of equal communication，informed consent informing and communication connotation needed to be improved；the satisfaction of doctors and patients with doctor-patient communication is inconsistency; the satisfaction of doctors（68.9%）was lower than that of patients（88.4%）; the doctors are due to busy work，lack of communication skills and awareness，etc，and patients lack of medical knowledge，high expectations of doctors，lack of risk assessment and trust and public opinion guidance，which are important factors affecting the effectiveness of doctor-patient communication. Results：doctors should focus on the following aspects containing increasing the connotation of humanistic care，standardizing informed consent informing，building a good communication environment，enhancing the use of communication skills，improve the communication ability of medical staff，etc. So as to build a harmonious doctor-patient relationship.