Stroke Population with High-risk Carotid Artery Atherosclerosis Dyslipidemia
2015年度社区、乡镇人群脑卒中筛查项目（GN?2015 F0001）
目的:探讨脑卒中高危人群早期颈动脉粥样硬化（ECAS）与血脂异常之间的关系。方法：2015年10月至2016年4月在扬州地区选取社区人群中≥40岁常驻居民为调查对象。通过脑卒中危险因素评估进一步确定脑卒中高危人群，进行统一的血液生化检测及颈动脉超声检查，分析血脂异常对ECAS的影响。结果：（1）994例（男性497）调查对象平均年龄63.21 ± 9.84岁，甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平升高及高密度脂蛋白胆固醇（HDL-C）水平降低的百分比分别为40.0%、11.5%、15.1%、9.5%；ECAS的患病率为48.5%；（2）ECAS组高TC百分比高于正常组（14.0% vs 9.3%，P=0.023）；高TG、高LDL-C、低HDL-C百分比组间比较无统计学差异；（3）在校正了相关混杂因素后，高TC发生ECAS的优势比是TC正常的1.8倍，而TG、LDL-C及HDL-C与ECAS无统计学上的关联。结论：脑卒中高危人群中TC升高与早期颈动脉粥样硬化独立相关。
Objective：To explore correlation between early carotid artery atherosclerosis（ECAS）and dyslipidemia in a population with high-risk of stroke. Methods：A community-based population aged 40 years or older were sampled between Oct. 2015 to Apr. 2016 in Yangzhou. Subjects with high-risk of stroke were selected by appraisal of risk factors and then given with blood tests and carotid artery ultrasonography. The effect of dyslipidemia on ECAS was analyzed. Results：（1）The average age of 944 subjects，out of which 497 were male，was 63.21 ± 9.84 years old. The proportion of elevated levels of TG，TC，LDL-C and reduced levels of HDL-C were 40.0%，11.5%，15.1%，9.5% respectively. The prevalence of ECAS was 48.5%.（2）The group of ECAS had a significantly higher proportion of elevated levels of TC in comparison with the normal carotid artery group（14.0% vs 9.3%，P=0.023），whereas there were not significant differences involving the proportion of elevated levels of TG，LDL-C and reduced levels of HDL-C between the two groups.（3）After adjustments for relevant potential confounders，elevated TC was still significantly associated with ECAS（OR=1.8），whereas TG、LDL-C and HDL-C were not significantly associated with ECAS. Conclusions：Elevated TC correlated independently with ECAS in a community-based population with high-risk of stroke.