目的：分析临床药师主导抗菌药物管理后抗菌药物使用强度（AUD）及抗菌药物使用率的变化，客观评价临床药师干预的有效性。方法：基于医院PASS临床药学管理系统，采集2022年1月至2024年12月住院患者抗菌药物使用情况数据，通过多维度干预措施（包括制度优化、培训宣教、医嘱点评、信息化审方及动态监测等）实施管理，比较干预前后AUD及抗菌药物使用率的变化。结果：干预后AUD由60.15±5.96 DDDs/100人·天降至42.76±4.95 DDDs/100人·天（P＜0.01），抗菌药物使用率由43.52%降至40.77%（P＜0.01），特殊级抗菌药物AUD呈反弹趋势。结论：临床药师干预可有效优化抗菌药物应用，但特殊级抗菌药物管理需强化多部门协同机制。

Objective：To analyze changes in antimicrobial use density（AUD）and antimicrobial utilization rate following clinical pharmacist-led antimicrobial stewardship interventions，and to objectively evaluate the effectiveness of clinical pharmacists’ involvement. Methods：Data on antimicrobial use from January 2022 to December 2024 were collected through the hospital’s PASS clinical pharmacy management system. Multidimensional interventions-including institutional optimization，training and education，prescription review，informatized prescription auditing，and dynamic monitoring-were implemented. Changes in AUD and antimicrobial utilization rates before and after the intervention were compared. Results：Post-intervention，AUD decreased significantly from 60.15±5.96 DDDs/100 patient-days to 42.76±4.95 DDDs/100 patient-days（P < 0.01），and the overall antimicrobial utilization rate declined from 43.52% to 40.77%（P < 0.01）. However，the AUD for special-grade antimicrobial agents showed a rebound trend. Conclusion：Systematic interventions led by clinical pharmacists effectively optimized antimicrobial use，but the management of special-grade antimicrobial agents requires strengthened multi-departmental collaboration mechanisms.