Abstract:Objective：To explore the construction of a new model and path for confidentiality work in public hospitals in the new era. Method：Taking a certain public hospital in Nanjing as an example，based on the Structure-Process-Outcome model，improve the organizational structure of the confidentiality work leadership group，optimize the management process of confidentiality work such as system construction，personnel management，document management，protective measures，publicity and education，supervision and inspection. Result：After the implementation of the SPO model，the 42 departments of the confidentiality work leadership group covered all functional departments，affiliated party committees，and branch areas of the hospital. The number of confidentiality work systems increased from 5 to 15，the number of personnel who obtained confidentiality qualification certificates increased from 5 to 14，and the pass rate of confidentiality work on-site inspections increased from 74.3% to 91.4%. Conclusion：The implementation of SPO model is of great significance in enhancing the confidentiality awareness of medical staff，promoting the transformation and upgrading of confidentiality work，and promoting the high-quality development of hospitals. It is worth implementing and applying in the field of confidentiality work in public hospitals.