Abstract:Objective：To evaluate the effect of implementing continuous interventions to improve the rate of antimicrobial pre-treatment pathogenicity delivery in a certain hospital. Methods：Patients who used antimicrobial drugs therapeutically during hospitalisation in the hospital were taken as the study subjects，and the inpatients in the first half of 2022 were the pre-intervention group，and a series of interventions were carried out from July 2022 to June 2023，and the inpatients in the second half of 2023 were the post-intervention group，and the rates of antimicrobial drug pre-treatment pathogenicity detection before and after the interventions were compared and analysed，as well as the rates of pathogenicity detection related to hospital infection diagnosis. and the rate of pathogenicity delivery related to hospital infection diagnosis. We also evaluated the response rate of medical personnel before and after the training. Results：A total of 14，234 patients were included in the therapeutic antimicrobial drug use，of which 4，739 cases were in the pre-intervention group and 9，385 cases were in the post-intervention group. After the implementation of the continuous intervention measures，the awareness of the medical staff of antimicrobial drug pre-treatment pathogenesis delivery and inspection was continuously improved，and the total pre-treatment antimicrobial drug pathogenesis delivery and inspection rates in the whole hospital，the surgical system，and the internal medicine system were 65.10%，64.74%，63.70%，respectively，which were higher than the pre-intervention rates of 57.27%，46.66%，and 67.29%，with statistically significant differences（P < 0.05）. After the intervention，the hospital-wide pre-treatment sentinel rate of the pre-treatment sentinel rate of key drug combinations reached 97.96%，which were higher than the pre-intervention rates of 85.45%，with statistically significant differences（P < 0.05），and the Hospital-wide hospital infection diagnosis-related delivery rate before and after the intervention did not significantly improve，the difference is not statistically significant（P > 0.05）outside. Through the special training of sending the test，the rate of passing the test increased from 60.13% before the training to 89.36%，and the knowledge rate was significant（χ2=68.156，P < 0.001）. Conclusion：The implementation of continuous interventions led to a significant improvement in the rate of antimicrobial pre-treatment pathogenetic delivery of antimicrobial drugs in the whole hospital，but the rate of hospital infection diagnosis-related delivery did not significantly increase，indicating that further targeted measures need to be implemented.