Abstract:Objective：To explore the care burden of the main caregivers of children with chronic critical illness and its influencing factors. Methods：Using the objective sampling method，116 main caregivers of children with chronic critical illness（CCI）hospitalized in PICU of a certaingrade A tertiary children’s hospital in Nanjing from January 2021 to December 2022 were selected as the study subjects，and their care burden was assessed using the general situation questionnaire and the Zarit caregiver burden scale. Results：The total score of ZBI of the main caregivers of CCI was（45.62 ±13.62），of which 10.9% had no or mild burden，29.3% had moderate burden and 59.8% had severe burden. Regression analysis showed that the medical payment method，the length of illness of the child，the monthly income per capita of the family，and the number of families participating in care affected the care burden of the main caregivers（P < 0.05）. Conclusion：The main caregivers of children with CCI generally have moderate and severe care burden. Attention should be paid to the main caregivers of families with long-term illness and poor economic status. It is recommended that medical staff reduce the burden of caregivers by increasing the publicity of medical insurance policies，carrying out home-based continuous nursing guidance，increasing social support and other measures.