Abstract:Objective：To explore the application of quality control circle activities in infection management of apheresis platelets，analyze and evaluate application effects. Methods：The QCC activity group was established. QCC management model was used to analyze existing problems，formulate countermeasures，monitor and evaluate the implementation effects. Results：After implementing quality control circle activities，the obedience of washing hands of medical staffs wereincreased，the incidence of occupational exposure decreased. Thedifferencesinthecorrectnessofhandwashing，infection control indicators，the correctness of medical waste classification and the accuracy of information management of raw and auxiliary materials are all statistically significant（P < 0.05）. The management indexes of platelet apheresis infection were improved，and all exceeded the target value. The sense of participation，enthusiasm，creative thinking，responsibility and honor，team cohesion，QCC techniques，communication and coordination and problem-solving skills of each circle member had been improved. Conclusion：QCC can improve the quality of infection control in the whole process of platelet apheresis，and the circle ability of each circle member.