Abstract:Objective：Through analyzing the information on the first page of medical records of malignant tumor patients admitted to a certainhospital in guangxifrom 2012 to 2021，we understood the prevalence and change trend of malignant tumor inpatients，so as to provide basis for the prevention and treatment of systemic malignant tumor. Methods：With the ICD-10 code of the International Classification of Diseases as the standard，the first page information of medical records which were first diagnosed as malignant tumor from January 1，2012 to December 31，2021 in a certainhospital in Guangxi was retrieved and analyzed retrospectively. Results：During the 10 years from 2012 to 2021，a total of 66，944 patients diagnosed with malignant tumor for the first time were treated in a hospital，including 33，513 males（50.06%）and 33，431 females（49.94%），and the number of inpatients with malignant tumor in 2019 was 1.35 times that in 2012. Among the hospitalized cases，patients with malignant tumors of liver and intrahepatic bile ducts rank first，accounting for 20.56%. The patients were mainly concentrated in the 45-64 age group，accounting for 54.99%. The average age of inpatient is 49.87 years old. 571 cases died in hospital，with the mortality rate of 0.85%. The mortality rate has shown a significant downward trend over the past ten years（P＜0.001）. The top 10 causes of death were liver cancer，lymphoma，lung cancer，gastric cancer，leukemia，colorectal cancer，ovarian cancer，pancreatic cancer，cervical cancer and esophageal cancer，accounting for 78.77% of all deaths caused by malignant tumors in hospital. The potential loss of life expectancy due to malignancy between 2012 and 2021 was 10，681.5 person-years（6，975 male-years and 3，706.5 female-years）. Malignant PYLL in men was higher than in females，and the difference was statistically significant（P < 0.001）. Conclusion：The number of patients with malignant tumor treated shows an increasing trend. The mortality rate drops year by year. The number of patients discharged due to malignant tumor shows an increasing trend year by year. Liver cancer ranks the first cause of death due to malignant tumor. Liver cancer，lung cancer，female breast cancer，gastric cancer，colorectal cancer，nasopharyngeal cancer and cervical cancer are the key malignant tumors to be prevented and treated in Guangxi. The prevention and treatment of key cancer species should be strengthened and the whole people should carry out cancer screening and early diagnosis and treatment. Various departments shall timely adjust prevention and treatment strategies and resource allocation according to the distribution of malignant tumors to carry out tertiary prevention of tumors and reduce the morbidity and mortality of malignant tumors.