Abstract:Objective：To explore effective management and control measures for the rational use of key drugs to provide reference for the supervision of key monitored drugs by medical institutions. Methods：This survey is based on the QRTCC model，focusing on the five elements of goals，rules，training，assessment，and culture. The hospital has implemented administrative intervention measures such as establishing systems，selecting catalogs，setting annual control targets，setting up prescription review expert groups and prescription review working groups，dynamic monitoring of usage，assessment and training，and other administrative intervention measures to achieve control of key monitored drugs. Result：This model is adopted to carry out refined management of the rational use of the key monitored drugs in our hospital. After the implementation of the plan，the hospital’s key monitoring drug revenue，the cost of key monitoring drugs used by inpatients，the intensity of drug use under key monitoring，and the unreasonable rate of doctors’ orders issued have all decreased significantly（P＜0.05）However，the improvement of the reasonable rate of doctor’s orders for Chinese patent medicines and special use of antibacterial drugs is not effective，and further research is still needed. Conclusion：Our hospital’s key monitoring drug control program based on the ORTCC model has achieved remarkable results. The use intensity and cost of key monitoring drugs have been significantly reduced，and the reasonable rate of doctor’s orders has been greatly improved. The implementation of the plan has raised the level of rational drug use in hospitals to a certain extent，ensured the safety of patients’ drug use and reduced the burden of medical treatment.