Abstract:Objective：To evaluate the quality of antimicrobial management in a hospital，and to provide data reference for antimicrobial drugs management. Methods：10 indicators in 4 dimensions related to antibiotics from 2012 to 2021 were obtained from the department of Pharmacy and department of infection controlin a certain tertiary hospital in Jiangsu，and the C value of the entropy TOPSIS method and the RSR value of the RSR method were used to jointly evaluate the management level of antibiotics. The ranking results of the method analyze the trend of management level in 10 years. Results：In 2020 and 2021，the antibacterial drug management department of our hospital was in the superior grade（3 grades）of the RSR model，and the C values were 0.912 and 0.938，respectively. In 2015，it was in the inferior grade（1 grade），and the C value was 0.237. The rest of the years are in the mid-range（level 2），the data is a jujube karyotype with two small ends and a large middle.The overall management level in 10 years has tortuousrisen in three stages. In the first stage，from 2012 to 2015，the C value rose slowly，but all were lower than 0.3；The stage is 2016-2018，the C values are 0.425，0.298，and 0.321，respectively，and the C value is in a state of fluctuation；the third stage is 2019-2021，and the C value has steadily increased and reached a higher level. In 20 and 21 reached above 0.9. Correlation analysis showed that there was a strong correlation between the results of the two models（r=0.942，P < 0.05）. Conclusion：The overall trend of antimicrobial drugsmanagement in our hospital is good. The results of entropy-weight TOPSIS combined with RSR to evaluate antimicrobialdrugsmanagement are scientific and credible，and are worthy of decision-making as the management basis.