Abstract:Objective：To explore the effect of nurse-led self-management combined with exercise rehabilitation nursing on self-management and cardiac function of patients with chronic heart failure（CHF）. Methods：A total of 146 CHF patients admitted to our hospital from June 2019 to November 2020 were enrolled and divided into 73 control groups and 73 observation groups according to the random number table method. On the basis of routine intervention in the control group，the observation group implemented nurse-led self-management combined with sports rehabilitation nursing. The cardiac function，self-management ability and plasma brain natriuretic peptide（BNP）and aldolase（ALD）levels were compared between the two groups. Results：The cardiac function，self-management ability，BNP and ALD levels of the two groups before nursing were compared，and there was no statistical difference（P > 0.05）.Compared with the control group，the observation group left ventricular ejection fraction（LVEF）and 6min walking distance after nursing（6MWT）is higher，N-terminal B-type natriuretic peptide（NT-poBNP）is lower，self-management ability score，BNP，and ALD levels are lower，with statistical differences（P < 0.05）. Conclusion：Based on nurse-led self-management combined with exercise rehabilitation nursing can enhance the heart function of CHF patients，improve self-management ability，and promote the improvement of the condition.