Abstract:Objective：To understand the basic situation of resigned personnel ina certain grade A tertiarygeneral hospital in Jiangsu Province in recent three years，so as to provide theoretical basis for hospital management，in order to reduce unnecessary brain drain and improve the talent team. Methods：The resignation information of regular employees from 2018 to 2020 was derived from the human resources management system of the hospital. The resigned employees were statistically analyzed by descriptive analysis，χ2 test and Bonferroni multiple comparison. P < 0.05 showed that the difference was statistically significant. Results：The total number of staff leaving the hospital from 2018 to 2020 was 123. The Department with the largest number of medical staff leaving the hospital was the anesthesia surgery department，and the nursing staff leaving the hospital were the anesthesia surgery department and pediatrics department.The turnover rate of full-time scientific research personnel，personnel with junior professional titles and personnel who have worked for less than 2 years is relatively high. Conclusion：The development channel of scientific researchers should be opened up and the supporting measures should be optimized. The workload of nursing staff in surgical system should be balanced，and bonus distribution and professional title promotion should be given preference to these nurses.The career development plan of new employees should be improved to increase their career stability.