Abstract:Objective：To understand the current situation of nursing staff organization support and occupational well-being in Yancheng area，and to analyze the relationship between the two，to provide theoretical basis for hospital managers，health administrative departments to human resources management，etc. To provide scientific reference for improving and promoting the nursing staff’s practice environment. Methods：Using random sampling method，1，879 nursing staff from 6 secondary and above public hospitals in Yancheng from March to April 2020were selected as the subjects of the study，and a questionnaire survey was conducted on their sense of organizational support and occupational well-being，and the relationship between the two was analyzed. Results：The total average score of nursing staff’s sense of organizational support was（48.50±10.73）points. The total average score of occupational well-being is（84.67±11.42）points. Comparing organizational support and occupational well-being between genders，jobs，laborforms，monthlyincome，marital status，differences are not statistically significant（P＞0.05）. Comparing different hospital types，age，educational background，working years，professional title，nursing staff’s sense of organizational support and occupational well-being，the difference was statistically significant（P < 0.05）. There was no statistical significance in comparing the organizational support of nursing staff at different hospital levels（P＞0.05）There was a statistically significant difference in occupational well-being（P < 0.05），and positively related the organizational support of nursing staff to occupational well-being（r=0.727，P=0.00）. Conclusion：The organizational support and occupational well-being of nursing staff in this area are at a high level，which can influence each other，and the hospital can improve the organizational support in management，pay attention to the physical and mental health of nurses，maintain the occupational well-being of nursing staff and stabilize the nursing team.