Abstract:Objective：To analyze the cost-benefit of syphilis intervention project in Shenzhen voluntary counseling and testing sites for AIDS，to evaluate the rationality of health resources utilization and the sustainability and extension of the project，and to provide basis for prevention and control of syphilis. Methods：According to the implementation of syphilis intervention project in HIV voluntary counseling and surveillance sites from 2014 to 2018.By comparing and assuming that the project has not been carried out，the syphilis patients among the consultants develop according to the natural course of syphilis，and the costs and benefits of the two ways，and the cost-benefit analysis of syphilis intervention project was carried out from the social point of view. Results：①96，722 cases of syphilis were screened from 2014 to 2018，1，890 cases of syphilis were found，the positive rate was 1.95%；1，175 cases of syphilis were treated，527 cases of second generation transmission were avoided，385 cases of third stage syphilis were avoided，265 cases of misdiagnosis and missed diagnosis were avoided. ②The total cost of the project was 16.3131 million yuan，the average screening cost was 147.74 yuan and the average treatment cost was 1722.23 yuan per case. The cost of the project was 8.247 million yuan when the project was not carried out，and the cost of syphilis patients was10，270.19 yuanper case. ③ The total benefit of the project is 366.6407 million? yuan，the net benefit is350.3276 millionyuan，and the cost-benefit ratio is 22.48. ④ Sensitivity analysis showed that the lower the incidence of third stagesyphilis and the probability of transmission ofsyphilis，the less the screening time，and the higher the treatment rate oflatent syphilis，the higher the cost-effectiveness of the project. Conclusion：The syphilis intervention project of Shenzhen voluntary counseling and monitoring agency for AIDS has good cost-effectiveness，and it is worth carrying out and promoting continuously.