Abstract:Objective：To explore the influence of social support，coping style，motivation and self-efficacy on self-care of young and middle-aged patients with hypertension at first diagnosis and to provide evidence for further intervention studies. Methods：Totally 287 young and middle-aged hypertension patients in Jiangyin were investigated with self-design general questionnaire，the High Blood Pressure Self-Care Profile，simple coping style questionnaire and socialsupport research scale. Results：Self-efficacy has direct positive effect on self-nursing behavior，motivation，positive coping style and social support have direct and indirect positive effect on self-nursing behavior. Conclusion：When providing self-care health guidance for young and middle-aged patients with newly diagnosed hypertension，medical staff should not only provide detailed self-care measures，but also pay attention to the patient’s self-efficacy，encourage patients’ relatives or friends to participate together，help the patient make rational use of social support，and face the disease in a positive way.