Abstract:Under the Corona Virus Disease 2019 epidemic，fever clinic is the first line of defense for screening suspected patients and blocking the spread of the epidemic. It has the characteristics of multiple suspected patients，rapid patient turnover，and high risk of infection. It is a huge challenge for prevention and control management. This article combines the practice of prevention and control of fever clinic and diagnosis in our hospital and shares the following experiences：First，a two-stage pre-check and triage system is adopted to set up pre-check and triage points at the entrance and exit of the hospital and emergency department，respectively，to screen new patients for Corona Virus Disease 2019；Secondly，on the basis of ensuring ventilation，rationally setting up wards，and following the “three-zone，two-passage” principle，rationally transform the fever clinic and set up a dedicated transfer path；Finally，combine the national requirements with the actual needs of the hospital to manage hospital infection，focusing on disinfection and sterilization，personal protection requirements，personnel training and medical waste treatment.