Abstract:Objective：To realize the rational use of antibacterial drugs and reduce the drug resistance rate of bacteria. Methods：Obtain the usage of Piperacillin Sodium and Sulbactam Sodium for Injection，the enterobacteriaceae bacteria resistant rate of third generations of cephalosporins and the average length of stay in gastroenterology quarterly from 2017 to 2018. Results：We found that the usage of Piperacillin Sodium and Sulbactam Sodium for Injection in the first three quarters year-on-year decline，but it rose in the fourth quarter from a year earlier. The resistance rate of enterobacteriaceae bacteria to the third generation cephalospora remained stable. The average length of hospital stays decreased significantly year-on-year. Conclusions：By improving the cooperation model of AMS，the tripartite cooperation of “antibacterial drug monitoring”，“microbial monitoring” and “nosocomial infection monitoring” should be established. Meanwhile，public publicity and education should be intensified to reduce the prevention of lactamase inhibitors.