Abstract:Objective：To investigate and analyze the epidemiological burden，medical service demand and medical expenses of malignant tumors in medical insurance population. Methods：Extract the general information and all new tumor case information in 2010-2014 of the medical insurance population in a city，use SPSS 21.0 software to calculate potential life loss year（YPLL），potential economic losses，used to evaluate the burden of malignant tumors. Results：Among the 41，145 patients，medical expenses totaled 5.739 billion，of which were composed of 3.168 billion yuan form survival patients and 2.570 billion yuan form dead patients. The medical expenses of the survival patients and the death patients with in 12 months after the onset of illness accounted for 50.7% and 53.71% of the total medical expenses respectively. The average loss of life of death cases was 15.2 years/case，and the average potential economic loss was 421，000 yuan/case. The medical expenses of last 12 months of death cases accounted for 69.8% of all medical expenses. The top three diseases with the highest potential economic losses were ovarian cancer，leukemia and cervical cervix cancer. Conclusion：The disease burden of patients with malignant tumors in the medical insurance population was heavy，which mainly comes from life loss，potential economic loss and medical expenses. The medical expenses are concentrated in 12 months after the onset and last 12 months of death case. The burden of women tumor is particularly prominent.