Abstract:Objective：To solve the problems existing in some party branches of the hospital，such as unclear principal responsibility，insufficient coordination，incomplete responsibility transmission，and imperfect accountability mechanism，etc，and set up the mechanism for implementing the responsibility for governing the party with strict discipline. Methods：The discipline inspection commission of hospital had made a series of practical explorations on the closed-loop management formed by the three aspects of knowing and clarifying responsibilities，fulfilling responsibilities and checking responsibilities. Results：The party branch had initially established the “coordination of four responsibilities” mechanism for comprehensively governing the party with strict discipline，namely，the main responsibility of the party branch，the supervision responsibility of the discipline inspection committee，the first responsibility of the party branch secretary，and the “one post and two responsibilities” mechanism for the department head. Conclusion：As an important working method provided by the “coordination of four responsibilities” mechanism for extending the party’s strict governance to the grass-roots level，it can make each responsible subject shoulder its own responsibilities. As an innovative work mode of the discipline inspection commission of hospital，it is necessary to further improve the mechanism in grassroots party branches of the hospital.