Abstract:Objective：To obtain the risk factors related to nosocomial infection by analyzing the nosocomial information in 2017 and 2018. Methods：The information in 2017 was completed by consulting medical records，conducting bedside surveys and filling in the questionnaire. The information in 2018 was extracted by the real-time monitoring system of Xinlin. Results：In 2017，37 patients had nosocomial infections，with the prevalence rate of 5.38% and case occurrence rate of 5.67%. In 2018 there were 42 nosocomial infections with the prevalence rate of 5.29% and case occurrence rate of 5.29%. The top three sites with highest prevalence rate were lower respiratory tract，skin and soft tissue，and urinary tract. The main pathogenic bacteria were Pseudomonas aeruginosa，Klebsiella pneumoniae，Escherichia coli and other gram-negative bacteria. The daily utilization rate of antibiotics was 37.06% in 2017 and 35.89% in 2018. The main purpose of using antibiotics agents was therapeutic. In 2018 and 2017，67.70% and 86.43% of the cases of treatment drugs were sent to the laboratory for bacterial culture. Conclusion：In 2017 and 2018，the prevalence rate of nosocomial infections，the detection rate and the rate of antibiotics use on investigation days all met the relevant national standards. However，the decrease in the rate of examination suggests that the weak consciousness of examination before the use of antibiotics is one of the risk factors for nosocomial infection.