Abstract:Objective：To analyze the management status of targeted drugs after being enrolled in medical insurance，and to provide reference for improving the insurance management policy of targeted drugs. Methods：The practice and exploration of special medicine management in Nantong was analyzed. Results：The special medicine management policy has relieved the economic burden of tumor patients and promoted the development of designated hospitals and pharmacies，but brung a risk for supervision of health care fund. Conclusions：It is necessary to strengthen the auditing system of responsible physician，to perfect the access conditions for patients with health insurance and to increase the qualifications for hospitals and pharmacies in district.