目的：了解抗菌药物专项整治前后，妇产科Ⅰ类切口手术围手术期预防使用抗菌药物合理性情况，为进一步加强管理提供理论依据。方法：采用回顾性研究方法，随机抽取抗菌药物专项整治前（2006年1月—2011年1月）与整治后（2012年1月—2017年1月）镇江市第四人民医院（镇江市妇幼保健院）妇产科Ⅰ类切口手术病历各100份，从有无预防使用抗菌药物和品种选择等6个方面进行统计分析，并将对照组和干预组进行比较。结果：干预组预防使用率降至18.00%，品种选择不合格率0.00%、用药指征不合格率16.67%、给药时机不合格率5.56%、疗程不合格率27.78%，各项指标较非干预组明显下降（P < 0.05）；用法用量不合格率16.67%（P＞0.05）。结论：采取干预措施后，该院妇产科Ⅰ类切口手术围手术期抗菌药物预防使用合理，干预措施有效，但不合理预防使用抗菌药物的现象仍偶有发生，需进一步建立长效管理机制。

Objective：To investigate the application of antibiotics in the perioperative period of type I incision surgery in the department of obstetrics and gynecology of a tertiary level-Ahospital before and after the special rectification of antimicrobial drugs，and to provide theoretical basis for further strengthening the management. To understand the rationality of preventing the use of antimicrobial agents. Methods：According to the retrospective study method, 100 medical records of the department of gynecology and obstetrics of a tertiary level-Ahospital before and after the special treatment of antibacterial were selected，and divided into the control group and the intervention group. Statistical analysis was carried out from 6 aspects，including the prevention and use of antibacterial and the selection of varieties，and the control group and the intervention group were compared. Results：The use rate of prevention in the intervention group dropped to 18.00%，the rate of nonconformance in variety selection was 0.00%，the rate of indications nonconformance was 16.67%，the rate of timing nonconformance was 5.56%，and the rate of course nonconformance was 27.78%.The unqualified rate of usage and dosage was 16.67%（P > 0.05）. Conclusions：After the intervention measures were taken，the preventive use of antibacterial drugs in the perioperative period of gynecological and obstetrictypeI incision surgery in the department of obstetrics and gynecology of this hospitalwas reasonable，and the intervention measures were effective.