Abstract:Objective：To ensure the continuity of patients’ diagnosis and treatment and to maintain the normal operation of hospitals in accordance with the requirements of the evaluation of tertiary hospitals. Methods：Starting from the analysis of the current situation of personnel vacancy，this paper lists several situations and causes of personnel vacancy. Taking Nanjing Jiangning Hospital as an example，PDCA cycle management tool was applied to personnel emergency substitution mechanism. Results：Through the application of PDCA，the vacancy situation of hospital staff has been significantly improved，the solutionsto sudden situation has been improved，and patients’satisfaction rate has been increased. Conclusions：The application of PDCA cycle in the field of emergency replacement of personnel is helpful to the improvement and development of hospital human resources and the maintenance of normal operation of hospital.