Abstract:Objective：To evaluate the clinical effect of Xipayi mouth rinse combined with vitamins in the treatment of recurrent oral ulcer. Methods：80 patients with recurrent oral ulcer who visited the hospital between January 2016 and December 2017 are randomly divided into two groups，40 patients in each group. The monotherapy group is treated with Xipayi mouth rinse，and the combination group added vitamins to treat ulcer surface.The serum levels of tumor necrosis factor α（TNF-α） are measured after treatment, and the healing time and therapeutic effect of the two groups are counted. Results：After a course of treatment，serum TNF-α levels were significantly decreased in both groups. Compared with the monotherapy group，the serum TNF-α level of the combination group is significantly improved（P < 0.01）. In addition，the healing time of ulcer in combination group is significantly lower than that in monotherapy group（P < 0.01）. The effective rate of the monotherapy group is 75%，while the effective rate of the combination group is 95%. There is significant difference between the two groups（P < 0.05）. Conclusion：Xipayi mouth rinse combined with vitamins in the treatment of recurrent oral ulcer has better effect，and is worthy popularizing.