Abstract:Objective：Through the introduction of the Industry 4.0 operation concept in comprehensive hospitals，with artificial intelligence，intelligent logistics，medical robots，collaborative service facilities，the modernization of hospital comprehensive service capabilities has been enhanced，creating intelligent hospital information system. Methods：This paper analyses the latest development of the Industry 4.0，combined with the actual medical services in the hospital，connectsIndustry 4.0 with both doctors and patients to optimize the quality of service to enhance the work efficiency，and introduces some application scenarios. Results：Through the application of this technology，the quality of medical service is improved and human resourceshave been saved. Conclusion：Conclusions can be drew from practices that the application of Industry 4.0 in the hospital can promote the upgrading of the medical industry，equipment and services to help hospitals improve productivity and operational force，realizing AI-HIS smart hospital.