Abstract:Objective：Exploring and analyzing the information management model and practice of the second class of psychotropic drugs in clinical rational application. Method：Limit the number of medication days，the total quantity of single prescriptions，the single maximum use as indexes，set up special prescriptions，and open green channels for special cases to achieve information management model of the second class of psychotropic drugs rational application of. Result：In view of the problems in the management of the second class of psychotropic drugs，the hospital puts forward effective technical interventions in the multi-sector cooperation，adopts the appropriate management strategy and applies the management pattern which conforms to the development of the times. Conclusion：Information management model takes the hospital pharmacy practical work needs as a starting point，dynamically monitoring hospital two types of psychotropic drugs application situation，not only practical，but also highly effective，scientific so on，which has a high promotion value.