Abstract:Objective：Medical insurance agencies are gradually implementing the “single-disease payment system”. Studying the rules of diagnosis and treatment of single-disease management，to control unreasonable costs，provide reasonable and scientific standards for payment，and change the traditional result evaluation to process evaluation. Methods：The ideal “upper limit” for the cost of the single diseases should be a cost-benefit measure that reflects the cost-savings based on the evidence-based clinical pathways and DRGs which guarantee medical quality. Conclusion：In the past one year， since the implementation of single-disease management in our hospital，objectively，not only ensuring the quality of medical treatment，raising efficiency of the hospital，lighting the economic burden on patients. However，because the diversity of diseases and the influence of uncontrollable factors such as medicines and consumables，some problems have also been found.