Abstract:Objective：To discuss the influences of medical price comprehensive reform on hospital economic operation in Jiangsu. Methods：Using a city hospital of Jiangsu as the research object，analyzed the changes of medical workload，balance of payments，income and cost structure，per capita cost and financial subsidy under the background of medical price comprehensive reform. Results：The experimental economic operation of the hospital ran smoothly with a steady increase in workload and appropriate control of the cost growth. The proportion of medicines dropped while medical income still maintained its growth. However，the operating costs rose with the expanding loss of payments balance. Conclusion: It suggested that the cost should be controlled in hospital level，while the input responsibilities should be implemented，the relationship between medical service and price should be rationalized，and the policy of medical insurance settlement should be improved in government level.