Weight Management Risperidone In Prison Schizophrenia Weight Body Mass Index
目的：探讨综合体重管理对利培酮导致的男性服刑精神分裂症患者体重增加的影响，以期探索能够有效控制并改善抗精神病药对服刑精神疾病患者体重增加的干预措施。方法：选取2015年8月至2016年5月在江苏省监狱管理局精神病院收治的服用利培酮的首发男性精神分裂症患者，分为对照组与干预组，对照组接受常规治疗和护理，干预组接受常规治疗和护理的同时，定期接受健康教育、培养良好的生活方式、饮食控制和运动干预等综合体重管理措施；分别于入组时、入组1个月、3个月及6个月，对两组患者体重和体重指数（BMI）进行测评。结果：（1）与对照组比较（66.98 ± 6.21，22.44 ± 1.03），综合体重管理1个月后，干预组体重和BMI评分（65.93 ± 7.38，21.76 ± 1.79）升高，但是差异均无显著性意义（P＞0.05）。（2）综合体重管理3个月后，干预组体重和BMI（67.34 ± 8.62，22.12 ± 2.36）显著低于对照组（70.01 ± 7.58，23.82 ± 2.12，P＜0.05）。（3）综合体重管理6个月后，干预组体重和BMI（66.18 ± 7.7，22.05 ± 1.87）极显著低于对照组（73.27 ± 10.28，24.24 ± 1.94，P＜0.01）。（4）组内相比发现，与入组时相比，对照组和干预组的体重和体重指数均增加，对照组的体重和体重指数逐在第3和6个月显著高于入组时；干预组的体重和体重指数在第1和3个月升高，而在第6个月呈下降的趋势，且仅在第3个月出现显著性差异。结论：综合体重管理能够显著控制并改善利培酮所致的男性服刑精神分裂症患者的体重和体重指数的增加。
Objective：To explore the effect of integrated weight management on the weight gain of patients with schizophrenia induced by risperidone，and to explore the effective measures to improve the weight gain of schizophrenic patients in prison induced by antipsychotic drugs. Methods：The first episode schizophrenias who taked risperidone in the psychiatric hospital of Jiangsu Province were choosed from Auguest 2015 to May 2016，and then divided into two group：control group and intervention group. The control group received routine treatment and nursing care. The intervention group received regular health education，training a good way of life，diet control and exercise intervention besides routine treatment and nursing care. The body weight and body mass index（BMI）of the two groups were evaluated at the beginning、first month、 third month and sixth month. Results：（1）Compared with the control group，the body weight and BMI score of the intervention group increased after 1 month of integrated weight management，but the difference was not significant（P > 0.05）.（2）The body weight and BMI（65.93 ± 7.38，21.76 ± 1.79）in the intervention group were significantly lower than those in the control group（66.98 ± 6.21，22.44 ± 1.03，P < 0.05）after 3 months of integrated weight managemen.（3）After 6 months of integrated weight management，the body weight and BMI（66.18 ± 7.7，22.05 ± 1.87）in the intervention group were significantly lower than those in the control group（73.27 ± 10.28，24.24 ± 1.94，P < 0.01）.（4）The body weight and BMI of all patients were increased compared with those at the beginning time. The weight and BMI of the control group were significantly higher than those at the beginning time at the 3rd and 6th month. The weight and BMI of the intervention group were significantly higher at the third month than those at the beginning time，but there was no significant difference in the first months and 6 months. Conclusion：Integrated weight management can significantly improve the body weight and body mass index induced by risperidone in patients with schizophrenia.