Abstract:To explore the operation management mode of loose regional medical coalition， and to give suggestions and opinions for promoting the hierarchical medical system. In the past year，there were several innovations in the management model of Wuxi People’s Hospital medical coalition，include system construction，operational process，information technology and so on.The specific tasks include developed integrated medical information platform，expert sinking，specialist assistance，training free clinics，two-way referral etc，carride out daily management and coordination work independently by the medical coalition office. The service process of medical coalition has been straightened out ,and realized the interoperability of medical information.