Abstract:Objective:To provide the basis of reducing craniocerebral surgical infection by the survey of main influencing factor of the class I craniocerebral surgical incision infection. Methods:Take the prospective study on allⅠcraniocerebral surgical incision datas from the date of of January 1,2015 to September 30,2015. Results:There were 169 patients who had the Ⅰcraniocerebral surgical were studied,including 85 male and 84 female.The result shows 13 cases were surgical site infected, the infection rate was 7.69%(13/169). The patients who were worsen prognosis or death, higher ASA risk anesthesia scores, blood transfusion during surgical operation ,none preoperative prophylactic use of antibiotics,surgical site infection rate could be increased,and the difference was statistically significant(P < 0.05). Conclusion:Many factors that affect the SSI should be combined with the conditions of the patients, strictly control each operation link,adopt significant preventive and control efforts,as far as possible to reduce the risk.